Exploring Nasal Anatomical Peculiarities: Illuminating Nasyakarma as a Paradigm Shift in Addressing Central Nervous System Disorders

The nasal route holds a special place in Ayurveda, particularly in the practice of Nasya karma. The nose, regarded as an opening to the "shiras" or head, possesses anatomical peculiarities that make it an ideal route for drug administration. The developmental origins of the nose lie in neural crest cells, which migrate during gestation, forming the nasal placodes and giving rise to the intricate nasal structure. Within the diverse approaches to drug delivery,nasya karma emerges as a promising carrier for brain-targeted therapeutics. This comprehensive review bridges modern pharmaceutical advancements with ancient Ayurvedic wisdom, emphasizing the significance of the nose as a crucial route for drug delivery and its potential role in treating central nervous system disorders.