Formulation and in vitro evaluation of gastroretentive accordion poly pill containing captopril and glibenclamide

Background: The study aims to create a new oral dosage form for patients with hypertension and diabetes, focusing on a sustained gastroretentive formulation.This dosage form will be easier to take, less frequent, and increase patient compliance, enhancing the effectiveness of glibenclamide and captopril, which are commonly used as hypoglycemic and anti-hypertensive agents.Materials and Method: This research study focuses on using the solvent casting process to develop and assess accordion pill films.The films are intended to offer a revolutionary polypill gastroretentive method and contain two key medications, glibenclamide and captopril.Different materials and processes were used to prepare different formulations, and the solvent casting method was used to formulate the films.The in vitro study assessed the accordion pill films' physical properties, drug release, and swelling behavior.It showed that these films could be used as gastro-retentive methods to distribute captopril and glibenclamide, which could enhance treatment regimens for cardiovascular disease and diabetes.Results: The results indicated that the drug content was high and that the materials were used consistently throughout the whole film.While all of the formulations had acceptable testing characteristics, The study analyzed drug release percentages over 13 hours, revealing that most formulations released 85% of the drug after 10 to 11 hours, with F6 and F7 being the best, with the highest release within 10 to 12 hours.It is demonstrated that all formulations followed fickian release and first-order kinetics.Conclusion: A viable poly pill gastroretentive method is presented by the formulation and in vitro evaluation of an accordion pill that combines glibenclamide and captopril utilizing the solvent casting process.Patients with diabetes and cardiovascular disease may benefit from more effective treatment plans thanks to the accordion pill films' extended stomach retention and regulated drug release capabilities.Validating the efficacy and safety of