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Background: Approximately 11 million burn injuries occur worldwide each year, causing significant morbidity and emotional distress. Burn wounds heal slowly, impacting quality of life. Mango peel contains flavonoids and mangiferin, which may aid burn wound healing. Objectives: This literature review aims to explore flavonoids and mangiferin in mango peel for burn wound healing. Methods: We searched PubMed, Google Scholar, Scopus, and Web of Science using keywords like burn wound, thermal injuries, flavonoid, mangiferin, and mango peel. We included accessible articles in Bahasa Indonesia or English, including research articles, systematic reviews, meta-analyses, and literature reviews. Discussion: Flavonoids enhance collagen synthesis and increase fibroblast basic growth factor and vascular endothelial growth factor, promoting granulation tissue formation. Mangiferin has anti-inflammatory properties, suppressing COX-1, COX-2, and PGE-2 production, and deactivating the NLRP3 inflammasome. These actions suggest potential for improving burn wound healing. Conclusion: Flavonoids and mangiferin in mango peel show promise for wound healing due to their anti-inflammatory, antibacterial properties, and ability to stimulate collagen and VEGF formation. Further research is needed for clinical application and better outcomes.
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Hanani et al. (2024) studied this question.
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