An efficient copper-catalyzed annulation of enaminones with maleimides has been developed. This reaction provides a practical approach towards the synthesis of various pyrrolo[3,4-e]isoindoles in moderate to good yields. Notable features of the method include the use of a 2-aminopyridine group as a traceless directing group, wide scope of substrates with good functional group compatibility and applicability to gram scale.
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Fu et al. (2024) studied this question.
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