Lipid Accumulation Product is a Novel Index Associated with Osteoporosis: Evidence from Two Independent Cross-sectional Chinese Populations

Objectives: The relationships between osteoporosis and obesity-related indices have been extensively investigated, but for the newly developed index, lipid accumulation product (LAP), its relationship with osteoporosis is unknown. This study aimed to explore the relationship between LAP and osteoporosis. Methods: A total of 2,128 and 3,384 elderly subjects were recruited from two Community Health Service Centers. These participants received anthropometric measurements, questionnaire investigations, bone density measurements, body composition measurements, and blood biochemical tests. Correlation analysis and multiple linear regression analysis were performed. Integrated discrimination improvement (IDI) and net reclassification improvement (NRI) were calculated to evaluate the risk prediction capabilities. Results: LAP and all conventional obesity-related indices positively correlated with bone mineral density (BMD) at the total hip and lumbar spine (LS) (P<0.001) in all subjects and in sex-classified subgroups. After adjustment for percentage fat mass, the positive correlation between LAP and BMD at the two sites was still statistically significant (P<0.05) (except for LS-BMD in females of Sample 1). Furthermore, IDI and NRI analyses indicated that the addition of LAP would significantly improve the ability to predict osteoporosis. Conclusion: Taken together, evidence from two independent cross-sectional Chinese populations indicates that LAP is a novel index associated with osteoporosis.