Key result
The highest quartile of lipid accumulation product was associated with a 2.32-fold increased risk of declined renal function compared to the lowest quartile.
Why the study?
Does a higher lipid accumulation product (LAP) predict declined renal function in the general Chinese population?
Cross-Sectional (n=10,012)
Yes
Does a higher lipid accumulation product (LAP) predict declined renal function in the general Chinese population?
Lipid accumulation product (LAP) is strongly associated with declined renal function and outperforms other obesity indices in predicting kidney impairment in the Chinese population.
Answers are grounded in this paper and cite their sources.
LAP may flag renal risk in Chinese adults; leaves open incremental value over standard predictors and need for prospective trials.
Lipid accumulation product (LAP) is a novel and effective index of visceral adiposity distribution based on waist circumference and triglycerides concentration. Few studies investigated the relationship between LAP and eGFR. We aimed to explore whether LAP was associated with declined renal function (eGFR < 60 mL/min/1.73m2), and also whether it exhibited obvious superiority in predicting kidney impairment compared with other obesity indices. In this cross-sectional study, 10,012 subjects were recruited from 22 sites in East China. LAP was calculated with the following formula: (WC-65) x TG for males, (WC-58) x TG for females. 4.7% participants with declined renal function had a higher LAP quartile. LAP was strongly associated with eGFR level (Beta: -0.073, P < 0.001) and declined renal function (P < 0.001) even after adjustment for age, sex, smoking, drinking, diabetes and hypertension. The risk of renal dysfunction increased 2.32-fold for the highest quartile LAP relative to the lowest quartile (OR: 2.32, 95%CI:1.52–3.53, P < 0.001). LAP exerted the largest area under the curve among different obesity indices (AUC ROC:0.644, 95%CI: 0.618–0.670, P < 0.001). Our findings showed that LAP strongly associated with declined renal function and could be one of markers for predicting the risk of renal dysfunction in the general Chinese population. ChiCTR-ECS-14005052 (WHO international clinical trials register platform in China). Registered 20 July 2014.
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Zhang et al. (2017) conducted a cross-sectional in Declined renal function (n=10,012). Lipid accumulation product (LAP) highest quartile vs. Lowest quartile of LAP was evaluated on Declined renal function (eGFR < 60 mL/min/1.73m2) (OR 2.32, 95% CI 1.52-3.53, p=<0.001). The highest quartile of lipid accumulation product was associated with a 2.32-fold increased risk of declined renal function compared to the lowest quartile.
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