Abnormal Changes of Cerebral Blood Flow in Hypertension with Different Risk Levels

Objective: The purpose of this study was to examine the different alterations in Cerebral Blood Flow (CBF) induced by hypertension across various risk levels. Materials and methods: A total of 121 hypertensive patients were classified into low-risk (n=30), moderate-risk (n=30), high-risk (n=31) and extremely high-risk (n=30) categories according to cardiovascular risk factors and target organ damage. We had 32 healthy individuals serve as a control group. CBF values of the whole brain and specific regions were retrieved using an Arterial Spin-Labeled (ASL) sequence. The CBF of the control group and varying hypertensive groups were analyzed using a Dunnett-t test. Univariate linear regression analysis was utilized to evaluate the relationship between Systolic Blood Pressure (SBP), Diastolic Blood Pressure (DBP), and CBF across all subjects, with P-values corrected via the False Discovery Rate (PFDR).