Key result
Systolic blood pressure was negatively related to cortical (β=-0.13, P=0.005) and hippocampal blood flow (β=-0.12, P=0.01), with mid-range SBP around 125 mm Hg maximizing perfusion in hypertension.
Why the study?
Relationships between blood pressure and cerebral blood flow, optimal blood pressure goals for brain perfusion, and effects on hippocampal perfusion remain poorly understood.
How does systolic blood pressure affect cortical and hippocampal perfusion in subjects with and without hypertension?
Population
Adults and elderly without dementia or clinically apparent stroke (cross-sectional n=445; longitudinal n=185)
Comparison
Subjects with vs without hypertension across blood pressure levels
Design
Cross-sectional and longitudinal study
Authors
Loading...
May support mid-range SBP targets for perfusion in hypertension; leaves open optimal thresholds pending prospective trials.
Cross-Sectional (n=445)
How does systolic blood pressure affect cortical and hippocampal perfusion in subjects with and without hypertension?
Effect estimate: β=-0.13 (cortical), β=-0.12 (hippocampal)
p-value: p=0.005 (cortical), 0.01 (hippocampal)
Cortical and hippocampal perfusion decrease with increasing systolic blood pressure, but in hypertensive patients, a mid-range SBP around 125 mm Hg appears to maximize perfusion.
Glodzik et al. (2018) conducted a cross-sectional in Without dementia or clinically apparent stroke (n=445). Systolic blood pressure was evaluated on Cortical and hippocampal blood flow (β=-0.13 (cortical), β=-0.12 (hippocampal), p=0.005 (cortical), 0.01 (hippocampal)). Systolic blood pressure was negatively related to cortical (β=-0.13, P=0.005) and hippocampal blood flow (β=-0.12, P=0.01), with mid-range SBP around 125 mm Hg maximizing perfusion in hypertension.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: