Preclinical study demonstrates that Nrf2 activation attenuates atherosclerosis in ApoE mice, suggesting a viable therapeutic target for vascular inflammation.
Nuclear erythroid 2-related factor 2 (Nrf2), a transcription factor, is critically involved in the regulation of oxidative stress and inflammation. However, the role of endothelial Nrf2 in atherogenesis has yet to be defined. In addition, how endothelial Nrf2 is activated and whether Nrf2 can be targeted for the prevention and treatment of atherosclerosis is not explored.
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He et al. (2024) studied this question.
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