The simple, rapid, precise, accurate, robust and economical analytical method has been developed for estimation of Ranolazine in bulk and pharmaceutical dosage form. This study describes the validation of an UV Spectrophotometric method for quantitative determination of Ranolazine in pharmaceutical dosage form using acetate buffer (pH 4.4) as solvent. The maximum absorbance was found at 272 nm. The Linearity was found to be in range of 5 to 40µg/ml. The %RSD for Intraday and Interday precision studies was found to be 0.793 and 0.793 respectively. The % assay was found to be 99.6%±0.05. The average % recovery of ranoalazine was found to be in between 98.5-101.7%. LOD and LOQ was found to be 0.58 µg/ml and 1.75 µg/ml respectively. The results suggest that this method can be employed for routine analysis of Ranolazine in bulk and commercial pharmaceutical formulations.
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P. Pravalika (2024) studied this question.
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