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Acute myeloid leukemia (AML) is a kind of malignant clone system disease of hematopoietic ancestor cells. Objects genetic modification plays an important role in the occurrence and development of AML. The current research shows that apparently, genetic modifications, such as DNA methylation, group protein modification, non-encoding RNA-mediated regulation, etc., play a key role in AML and become potential treatment targets. However, there are still research gaps in the targeted therapy for AML epigenetics, and further exploration and research need to be done. This article summarizes the epigenetic pathogenesis and types of AML and analyzes targeted therapeutic strategies for AML epigenetic modification, including DNA methyl metastase inhibitors, histone deaminase inhibitors, and non-encoding RNA. The results showed that these strategies showed potential treatment effects in preclinical and clinical studies and provided new ideas for AML treatment. The significance of this summary is to provide a reference for future AML therapy research, which indicates the importance of apparent genetic modification in AML treatment. However, there are still many problems that need to be solved, including the durability, drug resistance, and side effects of treatment. Future research can focus on these issues so as to bring more effective treatment plans to patients with AML.
Songci Zhou (Thu,) studied this question.