Assessment of Serum Vitamin D in Patients with Hypothyroidism in a Nigerian Tertiary Hospital

Introduction: Hypothyroidism is said to be associated with Vitamin D deficiency which is not routinely assessed in hypothyroid patients.The serum level of 1, 25 -dihydroxycholecalciferol and its link to hypothyroidism was assessed.Material and Methods: A total of 70 males and 90 females aged 20 -60 years were assessed for the study.Evaluation of serum 1, 25 -dihydroxycholecalciferol was done on ELISA monobind Inc.CA 92630, immuno -assay analyzer.Serum fT3, fT4 and TSH were also evaluated by enzyme linked immunosorbent assay (ELISA) technique using stat -fax -2100.Result: In our study, we have found the values of fT3 in the subjects as 1.21+ 0.89pg/ml lower than controls values of 1.92+0.66pg/ml,values of fT4 in subjects as 0.60+0.53ng/dlas compared to control group value of 1.40+0.30ng/dl,values of TSH as 2.07+1.19miU/Lhigher than the control group of 0.48+1.67miU/L.The mean values of 1, 25 -dihydroxycholecalciferol for subjects as 25.80+4.20 nml/L lower than the control group with 35.70+6.30.Conclusion: Our study findings suggest that patients with hypothyroidism also have low serum levels of 1, 25 -dihydroxycholecalciferol (Vitamin D) which can have implications related to numerous organ systems, such as the Bones, Kidneys, Cardiovascular, and Immunological systems.