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The study aims to evaluate the relationship between serum vitamin D3, calcium, and phosphate levels in hypothyroid women aged 45-85.

April 3, 2026Open Access

A Physiological Study on Levels of Vitamin D3 and Their Relationship With Calcium and Phosphate Levels in Hypothyroid Patients

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The study aims to evaluate the relationship between serum vitamin D3, calcium, and phosphate levels in hypothyroid women aged 45-85.
Conducted a case-control study with 80 hypothyroid females and 40 controls.
Measured serum vitamin D3 using electrochemiluminescence immunoassay.
Estimated serum calcium and phosphate levels spectrophotometrically.
Performed statistical analysis using SPSS with independent t-tests and Pearson correlation.
Hypothyroid patients had a mean serum vitamin D3 level of 13.40 ng/ml, significantly lower than the control mean of 31.15 ng/ml.
Calcium levels in hypothyroid patients were significantly lower at 8.05 mg/dl.
Phosphate levels in hypothyroid patients were significantly higher at 4.68 mg/dl.
A strong positive correlation between vitamin D3 and calcium (coefficient 0.712, p < 0.01) was observed.
A significant negative correlation between vitamin D3 and phosphate (coefficient -0.585, p < 0.01) was noted.

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A case-control study assesses mineral levels in hypothyroid women, indicating a need for routine monitoring.

BaidaaGhanemAlgam2 Marwa Ahmed Meri*1 (2026) studied this question.

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