Supplementary Figure S4 from Discovery of a Long Half-Life AURKA Inhibitor to Treat MYC-Amplified Solid Tumors as a Monotherapy and in Combination with Everolimus

Supplementary Figure S4. DBPR728 induces consecutive cell apoptosis. (A) Quantification of the pH3Ser10 and NEUROD1 levels in the xenografts measured by Western analysis (Fig. 4B). Errors are mean ± SD. *, P < 0.05; **, P < 0.01; ***, P < 0.001 (t-test, two-tailed). (B) Immunohistochemical analysis for the expression of cleaved Caspase-3 to mark apoptotic cells in NCI-H446 tumor xenografts harvested from mice described in Fig. 4A.