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June 3, 2024Journal of Medicinal Chemistry

Iterative Design of Near-Infrared Fluorescent Probes for Early Diagnosis of Alzheimer’s Disease by Targeting Aβ Oligomers

Bing Liu Xiaofang Li Zhengyang Liu Bing He Hanyue Xu Jianqin Cao Fantian Zeng Haiwei Feng Yanwei Ren Haoyu Li Tianyu Wang Jia Li Yuting Ye Li Zhao Chongzhao Ran Yuyan Li

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Abstract

Amyloid-β oligomers (AβOs), crucial toxic proteins in early Alzheimer's disease (AD), precede the formation of Aβ plaques and cognitive impairment. In this context, we present our iterative process for developing novel near-infrared fluorescent (NIRF) probes specifically targeting AβOs, aimed at early AD diagnosis. An initial screening identified compound

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Liu et al. (2024) studied this question.

synapsesocial.com/papers/68e665f2b6db6435875f21d8 https://doi.org/10.1021/acs.jmedchem.4c00252

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