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October 8, 2025Scientific ReportsOpen Access

Integrated systems biology reveals an 8-gene signature predicting early-stage lung adenocarcinoma progression and patient survival

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Authors

CYCorey D. YoungKCKaylin CareyCDCourtney D. Dill

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Overview

Systems biology analysis identifies a novel gene signature, suggesting improved survival prediction in lung adenocarcinoma.

Key Points

  • The identified 8-gene signature predicts progression and survival in early-stage lung adenocarcinoma.
  • The average AUC for the gene signature was found to be 75.5% across three timepoints: 12 months, 18 months, and 3 years.
  • This study utilized a systems biology approach analyzing TCGA transcriptomic data to uncover co-expression modules.
  • The findings indicate that the novel gene signature can enhance prognostic modeling and guide treatment in lung adenocarcinoma.

Cite This Study

Young et al. (2025) studied this question.

synapsesocial.com/papers/68e6679587ecc93a24d17438https://doi.org/10.1038/s41598-025-18567-w
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