Deaminative Functionalization of Olefins and Dienes with Katritzky Salts: A Highly Selective Route to Diverse Deuterium-Labeled Molecules

Herein, we report a deaminative alkylation of olefins, followed by deuteration that allows the formation of sp3–sp3 architectures. This protocol enables the previously unexploited functionalization of dienes with pyridinium salts, providing rapid access to complex molecules from bulk chemicals in a highly selective manner. Notably, the diversification of commercially available drug molecules particularly through deuteration is widely recognized as an effective strategy for drug discovery. Gratifyingly, this reaction facilitated the alkylation of drug- and amino acid-derived pyridinium salts, demonstrating both its synthetic versatility and potential utility in drug development.