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This is a Quantitative Study study.

October 8, 2025Frontiers in MicrobiologyOpen Access

Rotavirus A genotype diversity and antigenic profile in Central Ethiopia: implications for rotarix® vaccine efficacy

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Analysis reveals diverse genotypes and significant amino acid substitutions in rotavirus strains, suggesting vaccine performance may be compromised.

The predominant rotavirus A genotype detected was G9P[4], potentially affecting vaccine efficacy.
In total, 30 of 247 samples tested positive for rotavirus A, indicating a prevalence rate of 12.14%.
Phylogenetic analysis showed current strains cluster with previously reported Ethiopian strains, suggesting an evolutionary connection.
Substantial amino acid substitutions in current circulating strains compared to the Rotarix vaccine strain highlight concerns for vaccine performance.

Redda et al. (2025) studied this question.

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October 8, 2025Frontiers in MicrobiologyOpen Access

View Full Paper

Ask AI

Bookmark

Authors

Analysis reveals diverse genotypes and significant amino acid substitutions in rotavirus strains, suggesting vaccine performance may be compromised.

The predominant rotavirus A genotype detected was G9P[4], potentially affecting vaccine efficacy.
In total, 30 of 247 samples tested positive for rotavirus A, indicating a prevalence rate of 12.14%.
Phylogenetic analysis showed current strains cluster with previously reported Ethiopian strains, suggesting an evolutionary connection.
Substantial amino acid substitutions in current circulating strains compared to the Rotarix vaccine strain highlight concerns for vaccine performance.

Redda et al. (2025) studied this question.

View Full Paper

Ask AI

Bookmark