Exploring Phytomedicine’s Potential in Managing Parkinson’s Disease: Unveiling Neuroprotective Compounds from Medicinal Plants

Phytomedicine, derived from plants, offers potential in managing Parkinson’s symptoms due to its neuroprotective compounds. The review explores neurodegenerative diseases, focusing on Parkinson’s Disease (PD), emphasising its challenges, prevalence, and multifaceted aetiology. It delves into PD’s neuropathology, highlighting mitochondrial dysfunction, oxidative stress, and genetic factors while examining the current therapeutic approaches and their limitations. The paper investigates the neuroprotective potential of medicinal plants, particularly Bacopa monnieri, Curcuma longa, Camellia sinensis, Mucuna pruriens, Ginkgo biloba, and Withania somnifera in PD management. It details their impact on PD pathology, neuroprotective mechanisms, and effectiveness in preclinical models, underscoring their potential as alternative or adjunctive therapies for PD treatment. The review establishes these botanical compounds as promising avenues for novel therapeutic strategies against PD. Major Findings: Medicinal plants such as B. monnieri, M. pruriens, and C. longa demonstrate significant neuroprotective effects against Parkinson’s disease, highlighting their potential as alternative therapies to supplement current treatments.