Supplementary Figure S9 from Safety and Preliminary Efficacy of Pembrolizumab Following Transarterial Chemoembolization for Hepatocellular Carcinoma: The PETAL Phase Ib Study

Supplementary Figure S9. The productive Simpson clonality did not show any significant TACE-induced change when considering all samples analysed (A), and even after a further breakdown in responders (B) and non-responders (C). We did not observe any change in productive Simpson clonality when comparing samples collected before the start of pembrolizumab and at the end of treatment in the whole cohort (D), in responders (E) and non-responders (F). Abbreviations: TACE, trans-arterial chemoembolisation; ns, not significant; ICI, immune checkpoint inhibitor.