Optimal Control of General Impulsive VS-EIAR Epidemic Models with Application to Covid-19

In this work, we are interested in a VS-EIAR epidemiological model considering vaccinated individuals Vᵢ: i=1,…,n, where n∈ N*. The dynamic of the VS-EIAR model involves several ordinary differential equations that describe the changes in the vaccinated, susceptible, infected, exposed, asymptomatic, and deceased population groups. Our aim is to reduce the number of susceptible, exposed, infected, and asymptomatic individuals by administering vaccination doses to susceptible individuals and treatment to infected population. To achieve this, we utilize optimal control theory to regulate the dynamic of our considered epidemic model within a terminal optimal time τ*. Pontryagin's maximum principle (PMP) will be employed to establish the existence of an optimal control time (v*(t), u*(t)). We also incorporate an impulsive VS-EIAR epidemic model, with special attention given to immigration or the travel of certain population groups. Finally, we provide a numerical simulation to demonstrate the practical implementation of the theoretical findings.