Neutrophil Extracellular Traps in Myocardial Tissue Drive Cardiac Dysfunction and Adverse Outcomes in Patients With Heart Failure With Dilated Cardiomyopathy
Observational study reveals that myocardial neutrophil extracellular traps worsen cardiac dysfunction in dilated cardiomyopathy, highlighting a target for heart failure therapy.
Key Points
Neutrophil extracellular traps in myocardial tissue drive cardiac dysfunction and independently predict adverse clinical outcomes in dilated cardiomyopathy.
Among 62 patients undergoing biopsy, the 32 individuals with traps exhibited lower left ventricular ejection fraction and elevated B-type natriuretic peptide.
Fluorescent immunostaining and murine models reveal that ablating peptidyl arginine deiminase 4 prevents mitochondrial dysfunction; mouse model, limits apply.