HNO (azanone or nitroxyl), formally a product of the one-electron reduction of a nitric oxide, exhibits diverse and unique biological activity. The chemistry, biochemistry, and biological/pharmacological effects of HBO have been studied extensively. Due to rapid dimerization and hence short lifetime in solutions, in chemical and biological studies HNO is typically produced in situ from its thermal donors. To date, a great variety of chemical HNO donors have been synthesized, characterized, and utilized in biological studies. Here, we discuss the chemistry of HNO-releasing compounds, with the emphasis on the complexity of the proposed reaction mechanisms.
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Smulik-Izydorczyk et al. (2024) studied this question.
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