Key result
Acyloxy nitroso compounds act as nitroxyl (HNO) donors capable of vasorelaxation, with their biological activity depending on the kinetics of HNO release.
Population
Preclinical models (in vitro chemical assays and biological vasorelaxation assays)
Comparison
Acyloxy nitroso compounds vs Angeli's salt (for compound 3)
Design
Preclinical
Authors
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Supports further preclinical testing of HNO donors; leaves open clinical utility in vasorelaxation.
Acyloxy nitroso compounds represent a new class of nitroxyl (HNO) donors capable of vasorelaxation, with activity dependent on their specific HNO release kinetics.
Shoman et al. (2011) studied this question. Acyloxy nitroso compounds was evaluated on Hydrolysis rate, HNO release, and vasorelaxation properties. Acyloxy nitroso compounds act as nitroxyl (HNO) donors capable of vasorelaxation, with their biological activity depending on the kinetics of HNO release.
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