June 1, 2024Annals of the Rheumatic Diseases

Op0005 Navigating Complexities of Multiple Positive Myositis Autoantibodies: Analysis From Classification Criteria of Anti-Synthetase Syndrome (Class) Project

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Patients with multiple myositis-specific autoantibodies frequently display distinct clinical features coherent with each detected antibody.
Multiple positivities occurred in 305 of 2589 individuals, while line blot immunoassay yielded higher multiple positivity rates at 43.7%.
Retrospective and prospective study evaluated 2003 anti-synthetase syndrome cases and 2175 controls across 101 centers internationally.
Highlights that multiple seropositivities can reflect genuine autoimmune overlap syndromes rather than solely false positive assay artifacts.

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Implication

Observational analysis reports multiple myositis autoantibody positivities in anti-synthetase syndrome cohorts, suggesting true overlap syndromes exist.

Cite This Study

Loganathan et al. (2024) studied this question.

synapsesocial.com/papers/68e66db9b6db6435875f873b https://doi.org/10.1136/annrheumdis-2024-eular.3269

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Implication

Observational analysis reports multiple myositis autoantibody positivities in anti-synthetase syndrome cohorts, suggesting true overlap syndromes exist.

Op0005 Navigating Complexities of Multiple Positive Myositis Autoantibodies: Analysis From Classification Criteria of Anti-Synthetase Syndrome (Class) Project

Key Points

Discussion

Implication

Cite This Study

Op0005 Navigating Complexities of Multiple Positive Myositis Autoantibodies: Analysis From Classification Criteria of Anti-Synthetase Syndrome (Class) Project

Key Points

Discussion

Implication

Cite This Study

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Also Consider