Research progress in natural N-glycosides and synthetic methodologies for the formation of N-glycosidic bonds

N -glycosides comprise a broad range of compounds, some of which have demonstrated a variety of bioactivities, such as antiviral, antitumor, and antibacterial activities. Serving as essential building blocks for DNA and RNA, nucleosides are a particularly important subclass of N -glycosides. Accordingly, natural N -glycosides and their analogs have garnered great interests of both organic and pharmaceutical chemists, who have developed numerous synthetic methods for the preparation of N -glycosides. By reviewing the natural N -glycosides published between 1980 and 2023, this article summarizes current strategies for synthesizing N -glycosides, aiming to provide support for the development and research of N -glycosides.