Endocrinopathy and Slipped Capital Femoral Epiphysis

Research Article| June 01 2024 Endocrinopathy and Slipped Capital Femoral Epiphysis AAP Grand Rounds (2024) 51 (6): 65. https://doi.org/10.1542/gr.51-6-65 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Endocrinopathy and Slipped Capital Femoral Epiphysis. AAP Grand Rounds June 2024; 51 (6): 65. https://doi.org/10.1542/gr.51-6-65 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search toolbar search search input Search input auto suggest filter your search All PublicationsAll JournalsAAP Grand RoundsPediatricsHospital PediatricsPediatrics In ReviewNeoReviewsAAP NewsAll AAP Sites Search Advanced Search Topics: endocrine system diseases, epiphyses, slipped Source: Hwang S, Lee YJ, Song MH, et al. Incidence and clinical characteristics of slipped capital femoral epiphysis in patients with endocrinopathy: a population-based cohort study. J Bone and Joint Surg. 2024;106(5):381; doi: https://doi.org/10.2106/JBJS.23.00790.Google Scholar Investigators from the Seoul National University Children's Hospital, Seoul, South Korea, conducted a cohort study to compare the risk of slipped capital femoral epiphysis (SCFE) in youths with or without endocrinopathy and determine the incidence of SCFE in those with endocrinopathy. For the study, they reviewed data in the National Health Insurance Service database that includes demographic information, diagnoses, and treatments on health care encounters for >99% of the population of South Korea. Study participants were children in the database born between 2002 and 2005 who had a minimum of 14 years of follow-up data. Study children were classified as being in the endocrinopathy or no endocrinopathy cohort using ICD 10 diagnostic codes for 9 endocrinopathies. ICD 10 codes also were used to identify study participants with SCFE. The incidence of SCFE in the 2 cohorts was determined, and the relative risk (RR) for SCFE in those in the endocrinopathy cohort compared to those without endocrinopathy calculated. Subgroup analyses limited to males and females also were performed. The Cochran-Armitage test was used to assess the trend in incidence of SCFE relative to the number of endocrinopathies in a youth. Data were analyzed on 1,876,592 children, including 80.769 with endocrinopathy. Among those with endocrinopathy, 70% were female; 53% of those without endocrinopathy were male (P <0.001). A total of 191 participants were diagnosed with SCFE, with 30 cases of SCFE occurring in children in the endocrinopathy cohort. Overall, the incidence of SCFE was 10.2/100,000 children. The incidence of SCFE was significantly greater in children with endocrinopathy than in those without (37.1 and 9.0/100,000, respectively; RR, 4.1; 95% confidence interval [CI], 2.8, 6.1). The incidence of SCFE was significantly higher in males than females overall (RR, 2.0; 95% CI, 1.5, 2.7), in those with endocrinopathy (RR, 2.4; 95% CI, 1.7, 3.3), and in those without endocrinopathy (RR, 2.0; 95% CI, 1.0, 4.2). Among children with endocrinopathy, those with growth hormone deficiency had the highest incidence of SCFE (583.8/100,000 children). There was a significant trend between increasing number of endocrinopathies in a participant and the risk of SCFE (P <0.001). The mean age at diagnosis of SCFE was 11.6 ±1.7 years and was not significantly different among those with or without endocrinopathy. Among the 30 children with endocrinopathy-associated SCFE, the endocrinopathy diagnosis preceded the diagnosis of SCFE in 22 (73%). The median time between the diagnosis of endocrinopathy and SCFE in these patients was 3.6 years; 6 children were diagnosed with SCFE >5 years after their endocrinopathy diagnosis. The authors conclude that the risk of SCFE is significantly increased in youths with endocrinopathies. Dr Hennrikus has disclosed no financial relationship relevant to this commentary. This commentary does not contain a discussion... You do not currently have access to this content.