Incidence and outcomes of thromboembolic events in renal cancer related hospitalization in the United States: A propensity matched national study.

e16544 Background: Venous thromboembolic events (VTE) are a significant cause of morbidity and mortality in cancer patients. We aim to investigate the incidence and outcomes of acute DVT and PE in renal cancer compared to all other malignancies. Methods: The National Readmission Database (2016-2020) was queried to identify all-cause admissions for patients with any active malignancy. Cohorts were divided into renal cancer vs other cancers. A Propensity Score Matching (PSM) model matched both cohorts. Multivariate regression & Mahalanobis distance propensity matching were used to compare incidence rates and outcomes. Results: Among 1.2 million all-cause hospitalizations of patients with renal cancers, about 3.8% suffered an acute VTE. The majority had DVT (1.8%), followed by PE (1.4%) & DVT with PE (0.6%). On a propensity-matched & multivariate analysis, patients with renal cancers have a lower incidence of DVT (2.1% vs 2.8%, aOR: 0.76) & DVT with PE (0.7% vs 1%, aOR: 0.73) [p <0.001] as compared to other malignancies. Interestingly, rates of acute PE are similar to other malignancies (p>0.05). Among VTEs, acute PE was associated with the highest mortality (aOR: 3.17), followed by DVT with PE (aOR: 2.52) & DVT (aOR: 2.15) [p <0.001]. Resource utilization is also higher in renal cancers complicated by VTE, with patients suffering a DVT having the highest LOS (8 vs 3 days) & total cost of hospitalization ($24,403 vs $16,628) [p<0.001] followed by DVT with PE and only PE [p<0.05]. Interestingly, readmission rates are similar in patients with different VTEs (DVT, PE, or DVT with PE, p >0.05). Conclusions: Hospitalizations in renal cancers were less frequently complicated by venous thromboembolism as compared to other malignancies. Mortality was highest for PE while resource utilization was highest for the DVT group.