Engineered Surfaces That Promote Capture of Latent Proteins to Facilitate Integrin‐Mediated Mechanical Activation of Growth Factors (Adv. Mater. 23/2024)

Bone Regeneration In article number 2310789, Udesh Dhawan, Manuel Salmeron-Sanchez and co-workers report engineering an osteogenic platform comprising material-driven fibronectin nano-networks that capture latent transforming growth factor beta-binding peptide-1 (rLTBP1), enabling cells to use integrins to mechanically activate growth factors. This technology establishes a cornerstone in mechanobiology-based medicine.