Promoting Prosthesis-Soft Tissue Integration Through Micro-Nano Topographical Regulation of Tendon-Derived Stem Cell Differentiation: A Mechanobiological Strategy.

To address the challenge of poor prosthesis-soft tissue integration in jawbone defect repair, this study proposes a dual strategy encompassing 'mechanical adaptation' and 'biological regulation'. A micro-nano hierarchical structure was constructed on the surface of Titanium-6Aluminum-4Vanadium(Ti6Al4V) implants. Wavy micro-grooves were fabricated using ultraviolet laser etching to enhance mechanical anchoring and stress dissipation, while titanium dioxide nanotube arrays were generated through anodic oxidation to regulate cellular behavior. This composite structure improved the mechanical stability of the interface and promoted tenogenic differentiation of tendon-derived stem cells, thereby achieving simultaneous mechanical integration and biological healing. This study provides a novel approach to overcoming the clinical challenges associated with prosthesis-soft tissue integration.