June 1, 2024Journal of Clinical Oncology

Final results of a phase II study of lenalidomide-elotuzumab as maintenance therapy post-autologous stem cell transplant (AuSCT) in patients (Pts) with multiple myeloma (MM).

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Authors

STSheeba K. ThomasThe University of Texas MD Anderson Cancer Center JGJamie S GeorgeThe University of Texas MD Anderson Cancer Center CPClaudia M Morales de PartoviThe University of Texas MD Anderson Cancer Center

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Implication

Randomized trial demonstrates prolonged progression free survival with lenalidomide and elotuzumab maintenance in multiple myeloma, indicating substantial efficacy after stem cell transplant.

Key Points

Maintenance with lenalidomide and elotuzumab improves response depth in multiple myeloma, with complete response rates increasing from 37.7% to 69.3%.
Median progression free survival reached 75.4 months, and the estimated five-year overall survival rate was 86.7% during extended clinical follow-up.
Phase 2 trial evaluation across 100 participants demonstrates feasible autologous stem cell transplant consolidation, supporting enhanced dual maintenance therapy.

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Thomas et al. (2024) studied this question.

synapsesocial.com/papers/68e67069b6db6435875fb267 https://doi.org/10.1200/jco.2024.42.16_suppl.7509

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Implication

Randomized trial demonstrates prolonged progression free survival with lenalidomide and elotuzumab maintenance in multiple myeloma, indicating substantial efficacy after stem cell transplant.

Final results of a phase II study of lenalidomide-elotuzumab as maintenance therapy post-autologous stem cell transplant (AuSCT) in patients (Pts) with multiple myeloma (MM).

Discussion

Member takes

Implication

Key Points

Cite This Study

Final results of a phase II study of lenalidomide-elotuzumab as maintenance therapy post-autologous stem cell transplant (AuSCT) in patients (Pts) with multiple myeloma (MM).

Discussion

Member takes

Implication

Key Points

Cite This Study

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