June 1, 2024Annals of the Rheumatic Diseases

Op0069 Sequential B Cell/T Cell Therapy to Re-Induce Humoral Immune Tolerance in Acpa-Positive Rheumatoid Arthritis (Tolera): First Results From Phase 2, Open Label, Randomized Controlled Trial Comparing Rituximab and Abatacept With Rituximab Alone

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AKA. KleyerUniversitätsklinikum Erlangen DSD. SimonCharité - Universitätsmedizin Berlin SBSeda BAYATIğdır Üniversitesi

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Implication

Randomized trial finds sequential rituximab and abatacept fails to induce seroconversion in rheumatoid arthritis, indicating no enhanced humoral immune tolerance over rituximab alone.

Key Points

Sequential rituximab and abatacept therapy failed to induce anti-citrullinated protein antibody seroconversion or reduce autoantibody levels compared with rituximab alone.
Zero patients achieved seroconversion at week 52, while adjusted disease activity differences in rheumatoid arthritis remained non-significant at -0.07.
Randomized controlled trial evaluation highlights that combining abatacept with rituximab does not restore immune tolerance, calling for larger trials.

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Kleyer et al. (2024) studied this question.

synapsesocial.com/papers/68e67071b6db6435875fb59d https://doi.org/10.1136/annrheumdis-2024-eular.4932

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Implication

Randomized trial finds sequential rituximab and abatacept fails to induce seroconversion in rheumatoid arthritis, indicating no enhanced humoral immune tolerance over rituximab alone.

Op0069 Sequential B Cell/T Cell Therapy to Re-Induce Humoral Immune Tolerance in Acpa-Positive Rheumatoid Arthritis (Tolera): First Results From Phase 2, Open Label, Randomized Controlled Trial Comparing Rituximab and Abatacept With Rituximab Alone

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Cite This Study

Op0069 Sequential B Cell/T Cell Therapy to Re-Induce Humoral Immune Tolerance in Acpa-Positive Rheumatoid Arthritis (Tolera): First Results From Phase 2, Open Label, Randomized Controlled Trial Comparing Rituximab and Abatacept With Rituximab Alone

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Key Points

Cite This Study

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