Pos0406-HPR the Clinical Profiles of People With Knee Osteoarthritis With or Without a Prior Knee Surgery. A Registry-Based Study From the Swedish Osteoarthritis Register With 77 000 Individuals

Background: Osteoarthritis (OA) is the most common joint disease. A prior knee injury (with or without surgery) is a risk factor for OA and might represent a specific phenotype in knee OA. However, little is known about whether individuals with knee OA and a history of a prior knee surgery differ in individual and clinical characteristics from individuals with knee OA without a knee surgery. Possible specific characteristics of individuals with knee OA and a prior knee surgery, may promote more patient-centered care decisions in clinical practice. Objectives: To compare individual and clinical characteristics of individuals with knee OA with or without prior knee surgery. Methods: This observational registry-based study includes data from the Swedish Osteoarthritis Register between 2008-2022. The Swedish Osteoarthritis Register contains data about individuals participating in first-line OA treatment (education and exercise) in primary care in Sweden. Individuals with a self-reported prior knee surgery were compared to individuals without a prior knee surgery with regards to individual characteristics (sex, age, BMI) and clinical characteristics (Charnley classification, intake of OA medication, fear of movement, walking difficulties, willingness of surgery, physical activity level, pain, and health-related quality of life) using logistic regression and Odds ratio (OR). Results: The analysis included 77 791 individuals with knee OA of which 13 558 (21 %) reported a prior knee surgery. Individuals with a prior knee surgery had lower odds of being a woman (OR 0.439, 95% CI 0.416 to 0.464) were younger, (OR 0.957, 95% CI 0.954 to 0.959), had a lower BMI (OR 0.966, 95% CI 0.969 to 0.972), and less fear of movement (OR 0.913, 95% CI 0.852 to 0.979) compared to those without prior surgery. On the other hand, those who reported a prior knee surgery had higher odds of being physically active (OR 1.159, 95%CI 1.095 to 1.228), having walking difficulties (OR 1.856, 95%CI 1.744 to 1.975), having a wish for surgery due to OA symptoms (OR 1.856, 95%CI 1.744 to 1.975) and higher health-related quality of life (OR 1.228, 95% CI 1.028 to 1.466). There was no difference between individuals with and without a prior knee surgery for Charnley classification, pain intensity, pain frequency or intake of OA medication. Conclusion: Individuals with knee OA, with and without a prior knee surgery differ in both individual and clinical characteristics. Individuals with knee OA and a prior knee surgery seem to enter first-line treatment at a younger age, with a lower BMI, with less fear of movement, a higher level of physical activity, a higher self-reported health-related quality of life but with more walking difficulties and a higher willingness of surgery. These group differences need to be considered in clinical practice to enhance individualized OA treatment in this group of individuals. REFERENCES: NIL. Acknowledgements: NIL. Disclosure of Interests: None declared.