Ab0151 Comparison of Lipid Peroxidation Indices in Fibromyalgia and Myofascial Syndrome

Background: Numerous authors reported oxidative stress data in fibromyalgia (FM), however oxidative stress seems to be associated with other persistent pain syndromes as well. In our study we made an attempt to compare various lipid peroxidation indices in FM and myofascial syndrome (MFS). Objectives: To assess the oxidant system status in FM and MFS. Methods: A total number of 160 patients with chronic musculoskeletal pain were examined and assigned to fibromyalgia and myofascial syndrome groups accordingly. Early, intermediate and late lipid peroxides (u/l), serum malondyaldehide (MDA) (mkmol/l), serum total antioxidant activity (mmol/l), serum prooxidant activity (mkmol/l) were assessed in both groups with the following results. Results: An active peroxidation process was found in FM, and likewise in SMF, but with a lower expression. In both cases early and intermediate peroxidation predominates, but with a greater value in FM vs SMF: early lipid peroxides – 0,386±0,153 vs 0,324±0,086 (M±SD, p=0,002252); intermediate lipid peroxides 0,363±0,149 vs 0,214±0,053 (M±SD, p=0,000000); and late lipid peroxides 0,127±0,053 vs 0,098±0,027 (M±SD, p=0,000037). Conclusion: Both FM and MFS patients presented with signs of oxidative stress, slightly more expressed in FM than MFS. However, the FM group displayed a statistically significant lower anti-oxidant activity compared to MFS, suggesting that rather deficient anti-oxidant ability than excessive pro-oxidant activity cause the perpetuation of oxidative stress in FM patients. REFERENCES: [1] Cordero MD. Oxidative stress in Fibromyalgia: pathophysiology and clinical implications. Reumatol Clin 2011; 7: 281-283. Acknowledgements: NIL. Disclosure of Interests: None declared.