Pos0101 Mortality Trends in Polymyositis and Dermatomyositis in Mexico: A General Population-Based Study From 2000 to 2019

Background: Inflammatory myopathies refer to a group of autoimmune diseases that affect the skin and different organs, leading to disability and a significant economic burden. In recent years, health information has become available in open access, which allows us to assess the mortality rates of various diseases. Objectives: To assess mortality trends in polymyositis/dermatomyositis (PM/DM) in Mexico between 2000 and 2019, overall and by sex, age group, and geographic regions. Methods: Data were acquired from Health Information Open Access databases, and we identified deaths for PM/DM (ICD-10) recorded from 2000 to 2019. Age-standardized mortality rates (ASMR) per 100,000 persons were calculated for PM/DM and non-PM/DM overall, by sexes, and by geographic region. Annual percentage change (APC) in ASMR was calculated using Joinpoint regression software. Results: We found 1,456 deaths from PM/DM in Mexico from 2000 to 2019. The gender distribution of PM/DM deaths was 69.8% in women and 30.2% in men. Compared to non-PM/DM, PM/DM individuals had a higher proportion in the younger population (younger than 45 years) (40.2% vs. 22.3%). Overall, a significant downtrend in the ASMR was identified from 2007 to 2017 in subjects with PM/DM (APC -3.2%; 95% CI, -5.3 to -1.0; p = 0.008), while mortality trends were stable for non-PM/DM individuals. Similar trends were identified by sex in PM/DM patients. The Joinpoint analysis did not identify variation in temporal trends in mortality rates by geographic region; however, an increment in the proportion of deaths in the ratio of PM/DM to non-PM/DM ASMR was detected in the Northern and Southern regions (+17.6% and +84.9%, respectively). Conclusion: Over 20 years, we observed that deaths due to PM/DM occurred predominantly in females. A notable decrease in overall mortality rates was identified between 2007 and 2017. Differences by sex, age, and geographic region were also detected. REFERENCES: [1] Svensson J, Arkema E V, Lundberg IE, Holmqvist M. Incidence and prevalence of idiopathic inflammatory myopathies in Sweden: a nationwide population-based study. Rheumatology (Oxford). 2017 May;56(5):802–10. [2] Mendoza-Pinto C, Etchegaray-Morales I, Garcia-Carrasco M, Munguía-Realpozo P, Méndez-Martínez S, Osorio-Peña AD, et al. Twenty-year trends in all-cause mortality of patients with systemic lupus erythematosus in Mexico: Results from a nationwide health registry. Lupus. 2022;31(3):382–91. [3] Datos abiertos. Secretaría de Salud/Dirección General de Información en Salud [Internet]. Available from: http://www.dgis.salud.gob.mx/contenidos/basesdedatos/Datos_Abiertos_gobmx.html Acknowledgements: NIL. Disclosure of Interests: None declared.