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June 1, 2024Annals of the Rheumatic Diseases

Ab0653 Impact of Tsdmard, Tofacitinib, on Endothelial Function in Ra and Its Association With Cellular Ratios

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Authors

ASAshit SyngleIVI. VermaKCKhushbu Chauhan

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Overview

Clinical study shows improved endothelial function after tofacitinib therapy in rheumatoid arthritis, highlighting vascular benefits independent of cellular inflammatory ratios.

Key Points

  • Flow-mediated dilation increases from 7.14 to 8.22 after 12 weeks of tofacitinib therapy, demonstrating significant vascular improvement in active rheumatoid arthritis.
  • Assessment of vascular endothelial function using AngioDefender flow-mediated dilation evaluated patients with active rheumatoid arthritis receiving adjunct tofacitinib.
  • Highlights that peripheral cellular ratios fail to predict endothelial recovery, whereas tofacitinib reduces systemic inflammation and improves vascular health in rheumatoid arthritis.

Cite This Study

Syngle et al. (2024) studied this question.

synapsesocial.com/papers/68e671adb6db6435875fb907https://doi.org/10.1136/annrheumdis-2024-eular.4054
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1AB0623 IMPACT OF TOFACITINIB ON LIPID METABOLISM IN PATIENTS WITH RHEUMATOID ARTHRITIS: A REAL-WORLD STUDY2024
  2. 2Effect of tofacitinib therapy on angiotensin converting enzyme activity in rheumatoid arthritis2023 · 4 citations
  3. 3Trajectory of lipid profiles in rheumatoid arthritis patients receiving tofacitinib: Evidence from the prospective CENTRA cohort2026
  4. 4POS0107 IDENTIFICATION OF POTENTIAL GENES AND TREATMENT RESPONSE TO TOFACITINIB THERAPY IN PATIENTS WITH RHEUMATOID ARTHRITIS2024
  5. 5AB0777 IDENTIFICATION OF A MICRORNA SIGNATURE PREDICTIVE OF CLINICAL RESPONSE TO TOFACITINIB IN PATIENTS WITH RHEUMATOID ARTHRITIS2024