Ab0108 Elevated Risk of Valvular Heart Disease in Patients With Gout: A Population-Based Cohort Study

Background: Gout has been widely associated with cardiovascular health, but its relationship with incident valvular heart disease (VHD) remains uncertain. Objectives: To investigate the association between gout and VHD, and further explore the role of weight management within this context. Methods: We identified 10,930 patients with gout from the UK Biobank Cohort based on the combination of self-report and/or hospital diagnostic codes. The risk of VHD associated with gout was assessed in the overall populations and across subgroups with differing metabolic profiles. To examine the impact of obesity on the incident VHD, the relative risk of VHD were analyzed based on body mass index and waist circumference. Results: The incidence rate of VHD was significantly higher in patients with gout than in participants without gout (Hazard ratio 2.53, 95% confidence interval 2.35-2.71). While a positive correlation was observed between SUA level and VHD risk in the general population, the significant higher incidence of VHD was observed only in patients with SUA levels higher than 10 mg/dL among gout population. The elevated risk of VHD associated with gout remained consistently across subgroups with differing metabolic profiles. The impact of obesity on the incident VHD was notable among gout patients with SUA below 9.0 mg/dL, but less pronounced in those with SUA exceeding 9.0 mg/dL. Conclusion: This finding suggests a significant association between gout and VHD, emphasizing the need for screening and preventive efforts in patients with gout to mitigate the risk of VHD. REFERENCES: [1] Messika-Zeitoun D, Baumgartner H, Burwash IG, Vahanian A, Bax J, Pibarot P, et al. Unmet needs in valvular heart disease. Eur Heart J 2023;44:1862-73. [2] Feig DI, Kang DH, Johnson RJ. Uric acid and cardiovascular risk. N Engl J Med 2008;359:1811-21. [3] Lazzeroni D, Bini M, Camaiora U, Castiglioni P, Moderato L, Bosi D, et al. Serum uric acid level predicts adverse outcomes after myocardial revascularization or cardiac valve surgery. Eur J Prev Cardiol 2018;25:119-26. [4] Muiesan ML, Salvetti M, Virdis A, Masi S, Casiglia E, Tikhonoff V, et al. Serum uric acid, predicts heart failure in a large Italian cohort: search for a cut-off value the URic acid Right for heArt Health study. J Hypertens 2021;39:62-9. [5] Choi HK, McCormick N, Yokose C. Excess comorbidities in gout: the causal paradigm and pleiotropic approaches to care. Nat Rev Rheumatol 2022;18:97-111. Acknowledgements: This research was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (Grant Number: 2022R1F1A1072279). Disclosure of Interests: None declared.