AB1224 SYSTEMIC SCLEROSIS AND COURSE OF PREGNANCY - RESULTS FROM THE NATIONWIDE PREGNANCY REGISTER RevNatus

Background: Systemic sclerosis (SSc) is a rare systemic autoimmune disease characterized by widespread vascular dysfunction and progressive fibrosis of the skin and internal organs. Most previous reports on pregnancies in SSc are based on smaller retrospective collected cohorts and case reports [1]. Objectives: To describe the course of pregnancy in patients with SSc. Methods: We prospectively collected data on pregnancy outcomes in women with SSc through the nationwide Norwegian quality registry on pregnancy and rheumatic diseases (RevNatus) from 2017 – 2023. The women in this cohort were diagnosed with IDC-10 codes M34.0 (4), M34.1 (5), M34.8 (2) and M34.9 (7). 18 pregnancies in 17 women were recorded. Results: Median maternal age at birth was 34 years (SD = 4.2) and median disease duration was 4,5 years (SD = 7.9). 72 % were ANA positive, 39 % were anticentromere antibody positive and one women was positive for anti-topoisomerase I antibody. Six women had additional diseases; four had metabolic disease, one had psychiatric disease and one had inflammatory bowel disease. Two pregnancies were not planned. All pregnancies ended in live births with median gestational age at delivery of 38 weeks (range 28-42). Median birth weight was 2999 gram (SD = 632.6). 14 (78 %) had vaginal deliveries and 4 (22 %) had caesarean section (3 acute and 1 planned). One woman experienced preeclampsia and HELLP. Due to different and multiple scoring points during pregnancy we present mean of the highest reported values; self-reported patient global health 44.8 (SD 33.2), self-reported pain 29.3 (SD 22.7) and self-reported fatigue 53.3 (SD 26.4) on a visual analogue scale 0-100. Table 1. Pregnancy outcomes in 18 SSc pregnancies Conclusion: In this nationwide cohort with women with SSc we registered 4 pregnancies that resulted in preterm birth (≤ pregnancy-week 37). All pregnancies resulted in live births. However, SSc is a very heterogeneous disease, and only one patient had anti-topoisomerase I antibody. Our data support that women without serious organ manifestations may have uncomplicated pregnancies. REFERENCES: [1] Lazzaroni MG, Crisafulli F, Moschetti L, Semeraro P, Cunha AR, Neto A, Lojacono A, Ramazzotto F, Zanardini C, Zatti S, Airò P, Tincani A, Franceschini F, Andreoli L. Reproductive Issues and Pregnancy Implications in Systemic Sclerosis. Clin Rev Allergy Immunol. 2023 Jun;64(3):321-342. doi: 10.1007/s12016-021-08910-0. Epub 2022 Jan 18. PMID: 35040084. Acknowledgements: NIL. Disclosure of Interests: None declared.