Op0281 Statin Use and Risk of Total Joint Replacement of Knee and Hip Osteoarthritis Patients: Study Based on the French National Healthcare System Database

Background: Potential beneficial effect of statin use on osteoarthritis progression is discussed. Some observational studies suggested that statin use might be associated with radiological worsening, others did not show any protective effect and few studies a protective effect. Objectives: The aim of our study was to assess the risk of total knee or hip replacement among patients treated by statin versus patients without statin treatment in the French population. Methods: We conducted a nationwide population based cohort study using the french national healthcare system database (SNDS). We included all patients starting a statin treatment in 2018 and still on treatment on a regular basis until december 2022 and 800,000 unexposed patients randomly selected from the entire French population. The primary endpoints, occurrence of knee or hip arthroplasty, were studied using Cox models adjusted for age, gender and comorbidities. In order to assess the uncertainty around the results, a propensity score matching was performed in a sensitivity analysis to create 2 groups of comparable patients. Results: The cohort included 274,801 patients treated with statins and 795,491 patients without statins, after removing patients who met exclusion criteria. Mean age 60.2 and 56.1 years, female 41.9 % and 51.9 %, diabetis 24.0 % and 7.7 %, cardiovascular comorbidities 33.0 % and 7.0 % respectively. During follow-up 5,788 and 9,928 knee replacement and 5,347 and 10,170 hip replacement occured in the statin and non statin group, respectively. Risk of knee or hip replacement for the statin group versus non statin group was significantly higher: knee replacement HR 1.49 [1.44; 1.55] (p<0.0001); hip replacement HR 1.39 [1.34; 1.44] (p<0.0001). The results were confirmed by sensitivity analysis. Conclusion: This study showed that statin use is associated in a increased significant risk of knee and hip replacement. REFERENCES: NIL. Acknowledgements: NIL. Disclosure of Interests: None declared.