Potentilla fulgens: organic column purified extract and its effect on enzyme inhibition in the vector snail Lymnaea acuminata

Fasciola hepatica and F. gigantica are parasitic trematode that causes fascioliasis in cattle and humans. The vector snail Lymnaea acuminata is an intermediate host of the Fasciola species. The major preventive step against fascioliasis is the control of the host snail L. acuminata. Effect of sub-lethal concentration of (20% and 60% of 96h LC50) column purified extract of Potentilla fulgens on acid phosphatase (ACPase), alkaline phosphatase (ALPase), and acetylcholinesterase (AChE) inhibition in nervous tissue of host L. acuminata were studied. Alteration in the enzymes of ACPase, ALPase, and AChE in nervous tissue was time and concentration-dependent. Withdrawal experiment demonstrates that there was a significant recovery in ACPase, ALPase, and AChE inhibition in nervous tissues of L. acuminata were withdrawn from 7 days and treated with 20 and 60% of 96h LC50 for 96h. A significant recovery in the levels of ACPase, ALPase, and AChE was observed in the nervous tissue of L. acuminata. .