The present study was carried out to investigate the haematology, serum biochemistry, histopathology and isolation of causative bacterial agents from canine pyoderma cases.The highest occurrence of canine pyoderma was recorded in the age group between one to six years and particularly in male dogs.Affected dogs showed significant (P < 0.05) decrease in the haematological values like haemoglobin, total erythrocyte count and significant increase in the total leucocytes, absolute neutrophil and eosinophil counts.Reduced albumin, increased cholesterol levels in serum biochemistry and infiltration of neutrophils with nuclear debris in the superficial keratin layer of the epidermis in histopathological analysis were recorded in pyoderma-affected dogs.Forty bacterial isolates were identified as S. intermedius (n=17), S. schleiferi (n=10), S. aureus (n=5), P. aeruginosa (n=5) and E. coli (n=3) based on cultural and biochemical characters.The study was concluded with significant changes in haematological, serum biochemical parameters and isolation of S. intermedius from canine pyoderma cases as a major bacteriological agent.
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