Application of two-dimensional shear wave elastography ultrasound in diagnosis of breast cancer

Objective: To describe characteristics of 2D ultrasound and two-dimensional shear wave elastography (2D-SWE) breast tumors. Determinated the combined value of 2D-SWE and 2D ultrasound in diagnosis breast cancer. Subject and method: 107 female patients with breast tumors were assigned 2D ultrasound, measured shear wave velocity (SWV) internal tumor by 2D-SWE method, classified according to BIRADS 2013 and WFUMB guildes 2015. Compared with the histopathological biopsy results after surgery. Results: 107 female patients with 46 benign breast tumors, 61 malignant breast tumors. The mean SWV intenal malignant breast tumors 6.6 ± 1.7 m/s were higher than benign breast tumors 3.8 ± 1.2 m/s. The SWV cutoff point internal tumors in diagnosis breast cancer was 5.1 m/s with Se = 91.8%, Sp = 80.4%, AUC-ROC = 0.91. The combined 2D ultrasound and 2D-SWE in diagnosis breast cancer had Se = 90.2%, Sp = 84.8%, good concordance with histopathological biopsy results after surgery Kappa = 0.75. Conclusion: 2D-SWE improved the specificity of 2D ultrasound in diagnosis breast cancer by upgrading or downgrading the BIRADS classification based on tumors stiffness characteristics.