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June 1, 2024Journal of Clinical Oncology

Patients with hepatocellular carcinoma (HCC) who require multiple transarterial chemoembolization (TACE) treatments in quick succession and prediction of outcome.

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Authors

MOMahmoud OufGeorgetown UniversityPPPetra PrinsHenry M. Jackson FoundationSASamantha ArmstrongUniversity School

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Overview

Retrospective analysis shows rapid chemoembolization needs predict shorter survival in hepatocellular carcinoma, indicating that early systemic therapy may be beneficial.

Key Points

  • Patients requiring three or more transarterial chemoembolization rounds within six months had an overall survival of 25.8 months, compared to 49.4 months over longer intervals.
  • Retrospective analysis evaluated 167 individuals with hepatocellular carcinoma who underwent transarterial chemoembolization at a single institution between 2007 and 2021.
  • Rapid disease progression within six months highlights aggressive tumor biology, suggesting intermediate-stage cases need earlier transition to systemic therapy and immunotherapy.

Cite This Study

Ouf et al. (2024) studied this question.

synapsesocial.com/papers/68e673ffb6db6435875fea77https://doi.org/10.1200/jco.2024.42.16_suppl.e16208
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Treatment for intermediate and advanced-stage hepatocellular carcinoma: does systemic therapy synergize the therapeutic efficacy of TACE?2026
  2. 2Transarterial Chemoembolization for Hepatocellular Carcinoma in Clinical Practice: Temporal Trends and Survival Outcomes of an Iterative Treatment2022 · 20 citations
  3. 3Optimizing the sequencing and timing of transarterial chemoembolization and systemic therapy in advanced hepatocellular carcinoma.2026
  4. 4A Retrospective Cohort Analysis of Transarterial Chemoembolization for Hepatocellular Cancer at a Tertiary Center in Switzerland2024 · 2 citations
  5. 5Transarterial chemoembolization for advanced hepatocellular carcinoma after failure of first-line systemic treatment: a single-center case series2025