A Novel Drug Delivery: Nanocochleates

Dr. Dimitrious Papahadjoupoulos and his team found cochleates as precipitates formed by the interaction of negatively charged phosphatidylserine with calcium.They are used to provide vaccinations by delivering peptides and antigens.In nanocochleates, a new drug delivery vehicle, the targeted drug molecule is enclosed in a multi-layered structure including a solid-lipid bilayer within a spiralshaped sheet.Encochleation of the drugs is used in this approach to overcome issues such poor solubility, permeability, and oral bioavailability.They protect the molecule from harsh environmental conditions like pH, temperature, and enzymes.Because it has both hydrophilic and lipophilic forms on its surface and in its structure, it can contain both hydrophilic and lipophilic drug molecules.The loading capacity of the drug molecule to encapsulate is determined by the physical structure of the cochleates, while the encapsulation procedure defines the particle size of the complex formed.It can be used to deliver biologically active substances orally and systemically, including medications, DNA, proteins, peptides, and vaccine antigens.This method can be used for systemic as well as oral therapeutic delivery, and it may eventually be developed into a drug delivery system.These factors will encourage researchers to look into this emerging field of drug delivery technology.There are numerous methods for creating nanocochleates, which can then be used to administer different active compounds for a range of applications.This article discusses the composition and structure of nanocochleates as well as the drug administration mechanism, manufacturing techniques, assessment, uses, and limitations of these compounds.