The cGAS–STING Pathway is A Source of Potential Therapeutic Targets for Atherosclerosis Treatment

The cyclic GMP-AMP synthase (cGAS) – stimulator of interferon genes (STING) pathway presents promising therapeutic targets for the treatment of atherosclerosis. This review article explores the discovery of DNA sensing by cGAS-STING, insights into the signal transduction cascade of the pathway, its activation in disease contexts, and its role in senescence, autoimmune and inflammatory diseases. Furthermore, the article delves into the involvement of STIM1 in atherosclerotic plaque development and investigates the potential regulatory mechanisms of STIM1/cGAS-STING in atherosclerosis. Overall, a comprehensive understanding of the cGAS-STING pathway's role in inflammatory and autoimmune disorders may offer new perspectives for developing treatments for these conditions.