Circulating myo-miRs in physical exercise

MicroRNAs (miRs) are pivotal in regulating gene expression and orchestrating adaptive responses to physical exercise. This review delves into the dynamic interplay between exercise and circulating muscle-specific miRs (myo-miRs), with a specific focus on endurance and resistance training modalities. Endurance exercise, involving moderate to high-intensity activities, triggers acute and sustained changes in circulating myo-miRs levels, mirroring physiological adaptations in muscle tissue. Conversely, resistance exercise, emphasizing high-intensity, short-duration activities, elicits diverse responses in circulating myo-miRs, particularly in older individuals. Moreover, training interventions in endurance and resistance exercises yield distinct effects on circulating miR profiles, underscoring the relationship between exercise type, intensity, and duration. The potential of circulating myo-miRs as biomarkers to monitor exercise-induced muscle adaptations and the mechanisms behind their release into the circulation are promising areas for future research. Understanding the role of miRs in mediating systemic physiological responses to exercise could pave the way for innovative therapeutic strategies, enhancing muscle function and promoting overall health and well-being.