Sustainable Solvents in Metallaphotoredox Catalysis

Metallaphotoredox chemistry has emerged as a powerful tool to access synthetically challenging motifs in a rapid and efficient manner. Generally, photoredox catalysis is recognized as a green technology, avoiding highly reactive chemicals and using ambient temperatures. Nevertheless, solvent choice is often overlooked with commonly used hazardous sulfoxides, ethers, and amides such as DMF or DMAc. Herein, we emphasize the importance of sustainable solvents in photoredox chemistry and their application to process chemistry. We present alternative conditions for two of the most utilized photocatalytic reactions in the pharmaceutical industry.