Diosmin Ameliorates Aluminium Induced Neurotoxicity in the Hippocampus and Cortex of Male Wistar Rats: A Behavioural, Biochemical and Molecular Approach

Background: Aluminium is an omnipresent metal on the Earth's crust that has wide application in human lives.This increases the burden of Aluminium metal exposure and consequent deposition of it within the body.Several animal studies have shown Aluminium deposition in the brain over a chronic period leads to neurotoxicity, and eventually trigger other neurodegenerative diseases particularly Alzheimer's disease.In the emerging need of new therapeutic agents, Diosmin, a plant flavone was chosen to study the anti-neurotoxicity effects against Aluminium neurotoxicity.The present study aimed in evaluating the effect of Diosmin on Aluminium Chloride induced behavioural impairments, and its consequent changes in the biochemical parameters.neurotransmitter enzyme, and neurotrophic factors were also assessed in the study.Methods: Briefly, Diosmin (50mg/Kg) was administered orally 1 hour prior to the induction of Aluminium Chloride (4.8mg/Kg) through the intraperitoneal route for 28 days.At every 7 th day the behavioural paradigms were conducted.On the completion of the treatment schedule, the animals were sacrificed and, the Hippocampus and the Cortex regions were dissected and taken for biochemical and molecular analysis. Results:Our results indicate a statistically significant impairment in the Spatial and Learning Memory in the Aluminium Chloride induced rats, followed by diminished Motor Coordination.The biochemical assessments indicated an elevation in Oxidative Stress markers with