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May 31, 2024Nihon Kessho GakkaishiOpen Access

Basis of Potent Neutralizing Activity Revealed by Structural Analysis of SARS-CoV-2 Spike Proteins in Complex with Neutralizing Antibodies

Akifumi Higashiura Akima Yamamoto Takemasa Sakaguchi Tomoharu Yasuda

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Abstract

Here, we analyzed broadly neutralizing antibodies isolated from long-term hospitalized convalescent patients of early SARS-CoV-2 strains. Antibodies named NCV2SG48 and NCV2SG53 are highly potent to broad SARS-CoV-2 variants. To reveal the mode of action, we determined the crystal structure of the Fab fragment of NCV2SG48 or NCV2SG53 in a complex with RBD of the S proteins from the Wuhan-Hu-1 and Omicron BA.1.

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Higashiura et al. (2024) studied this question.

synapsesocial.com/papers/68e6794eb6db643587602f5d https://doi.org/10.5940/jcrsj.66.115

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