Why the study?
There was an urgent need to understand the molecular basis for immune recognition of SARS-CoV-2 spike glycoprotein antigenic sites and define the genetic and structural basis for neutralization.
Population
SARS-CoV-2 RBD and human monoclonal antibodies COV2-2196 and COV2-2130
Design
Structural, deep mutational scanning, and neutralization escape selection study
Authors
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May support investigational cocktail use against RBD variants; leaves open clinical efficacy and escape at mapped residues.
The structural characterization of the AZD7442 antibody cocktail demonstrates its mechanism of neutralizing SARS-CoV-2 and its efficacy against emerging variants of concern.
Dong et al. (2021) studied this question.
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